Have animal models of disease helped or hindered the drug discovery process? / Ann Jacqueline Hunter Current models and strategies in the development of antiobesity drugs / James S. Kinsey-Jones and Kevin G. Murphy Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms / Dennis Bruemmer ... [et al.] Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations / Nick Andrews ... [et al.] Animal welfare and the 3Rs in European biomedical research / Dominic J. Wells Best practices for the use of animals in toxicological research and testing / William S. Stokes Progress toward generating informative porcine biomedical models using induced pluripotent stem cells / Franklin West and Steven Stice A knockout mouse resource for the biomedical research community / K.C. Kent Lloyd Minimizing strain influences in a genetically modified mouse phenotyping platform / Michael D. Hayward, Olesia Buiakova, and David S. Grass The blessings and curses of C57BL/6 substrains in mouse genetic studies / Camron D. Bryant Modeling inflammation and microvascular dysfunction / Felicity N.E. Gavins TRPV1 and TRPA1 channels in inflammatory pain : elucidating mechanisms / Susan D. Brain Imaging of endocrine gene expression in a humanized transgenic rat / Julian R.E. Davis Systems biology of the heart : hype or hope? / T. Alexander Quinn and Peter Kohl Is it time for in silico simulation of drug cardiac side effects? / Gary R. Mirams and Denis Noble Human stem cell-derived cardiomyocytes for pharmacological and toxicological modeling / Sian E. Harding Humanized mice as a preclinical tool for infectious disease and biomedical research / Leonard D. Shultz ... [et al.] Humanized mice for the study of type 1 and type 2 diabetes / Dale L. Greiner ... [et al.] Deconstructing hepatitis C virus infection in humanized mice / Marcus Dorner and Alexander Ploss Animal models got you puzzled? : think pig / Eric M. Walters ... [et al.]. |